[Muffet tilts her head thoughtfully, giving the answer due consideration.]

Hmm, let's see... I know that Shepard is certainly a much more experienced fighter than I am, as is Roy... I recall that Lunafreya has some knowledge of how to speak properly to deities, which I'm sure is useful here, and Newt knew a few useful tricks for chemistry that I wasn't familiar with before.

Really, everyone knows something useful, it's just a matter of finding the situation where it comes in handy.